Pharmacodynamics of dose-escalated ‘front-loading’ polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli

Objectives: Gram-negative bacteria harbouring the mcr-1 plasmid are resistant to the ‘last-line’ polymyxins and have been reported worldwide. Our objective was to define the impact of increasing the initial polymyxin B dose intensity against an mcr-1-harbouring strain to delineate the impact of plas...

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Dades bibliogràfiques
Publicat a:J Antimicrob Chemother
Autors principals: Smith, Nicholas M., Bulman, Zackery P., Sieron, Arthur O., Bulitta, Jürgen B., Holden, Patricia N., Nation, Roger L., Li, Jian, Wright, Gerard D., Tsuji, Brian T.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890756/
https://ncbi.nlm.nih.gov/pubmed/28505268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx121
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