New Dosing Strategies for an Old Antibiotic: Pharmacodynamics of Front-Loaded Regimens of Colistin at Simulated Pharmacokinetics in Patients with Kidney or Liver Disease

Increasing evidence suggests that colistin monotherapy is suboptimal at currently recommended doses. We hypothesized that front-loading provides an improved dosing strategy for polymyxin antibiotics to maximize killing and minimize total exposure. Here, we utilized an in vitro pharmacodynamic model...

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Bibliographic Details
Main Authors: Rao, Gauri G., Ly, Neang S., Haas, Curtis E., Garonzik, Samira, Forrest, Alan, Bulitta, Jurgen B., Kelchlin, Pamela A., Holden, Patricia N., Nation, Roger L., Li, Jian, Tsuji, Brian T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957851/
https://ncbi.nlm.nih.gov/pubmed/24342636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00327-13
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