Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli

OBJECTIVES: To determine whether the spectrum of mutations in marR in ciprofloxacin-resistant clinical isolates of Escherichia coli shows evidence of selection bias, either to reduce fitness costs, or to increase drug resistance. MarR is a repressor protein that regulates, via MarA, expression of th...

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Bibliographic Details
Published in:J Antimicrob Chemother
Main Authors: Praski Alzrigat, Lisa, Huseby, Douglas L, Brandis, Gerrit, Hughes, Diarmaid
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890708/
https://ncbi.nlm.nih.gov/pubmed/28962020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx270
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