CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells

OBJECTIVE: Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited therapeutic options for advanced colorectal cancer (CRC), particularly for tumours carrying RAS-activating mutations. The aim of this stud...

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Dades bibliogràfiques
Publicat a:Gut
Autors principals: Manic, Gwenola, Signore, Michele, Sistigu, Antonella, Russo, Giorgio, Corradi, Francesca, Siteni, Silvia, Musella, Martina, Vitale, Sara, De Angelis, Maria Laura, Pallocca, Matteo, Amoreo, Carla Azzurra, Sperati, Francesca, Di Franco, Simone, Barresi, Sabina, Policicchio, Eleonora, De Luca, Gabriele, De Nicola, Francesca, Mottolese, Marcella, Zeuner, Ann, Fanciulli, Maurizio, Stassi, Giorgio, Maugeri-Saccà, Marcello, Baiocchi, Marta, Tartaglia, Marco, Vitale, Ilio, De Maria, Ruggero
Format: Artigo
Idioma:Inglês
Publicat: BMJ Publishing Group 2018
Matèries:
Colon
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890648/
https://ncbi.nlm.nih.gov/pubmed/28389531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312623
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