rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs

Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an attractive target for treatment of immune complex-mediated pathomechanisms. High-dose IVIG is used to treat aut...

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Veröffentlicht in:J Immunol
Hauptverfasser: Spirig, Rolf, Campbell, Ian K., Koernig, Sandra, Chen, Chao-Guang, Lewis, Bonnie J. B., Butcher, Rebecca, Muir, Ineke, Taylor, Shirley, Chia, Jenny, Leong, David, Simmonds, Jason, Scotney, Pierre, Schmidt, Peter, Fabri, Louis, Hofmann, Andreas, Jordi, Monika, Spycher, Martin O., Cattepoel, Susann, Brasseit, Jennifer, Panousis, Con, Rowe, Tony, Branch, Donald R., Baz Morelli, Adriana, Käsermann, Fabian, Zuercher, Adrian W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: AAI 2018
Schlagworte:
Autoimmunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890536/
https://ncbi.nlm.nih.gov/pubmed/29531170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701171
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