rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs

Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an attractive target for treatment of immune complex-mediated pathomechanisms. High-dose IVIG is used to treat aut...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Spirig, Rolf, Campbell, Ian K., Koernig, Sandra, Chen, Chao-Guang, Lewis, Bonnie J. B., Butcher, Rebecca, Muir, Ineke, Taylor, Shirley, Chia, Jenny, Leong, David, Simmonds, Jason, Scotney, Pierre, Schmidt, Peter, Fabri, Louis, Hofmann, Andreas, Jordi, Monika, Spycher, Martin O., Cattepoel, Susann, Brasseit, Jennifer, Panousis, Con, Rowe, Tony, Branch, Donald R., Baz Morelli, Adriana, Käsermann, Fabian, Zuercher, Adrian W.
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2018
Assuntos:
Autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890536/
https://ncbi.nlm.nih.gov/pubmed/29531170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701171
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