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Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica

Intravenous human immunoglobulin G (IVIG) may have therapeutic benefit in neuromyelitis optica spectrum disorders (herein called NMO), in part because of the anti-inflammatory properties of the IgG Fc region. Here, we evaluated recombinant Fc hexamers consisting of the IgM μ-tailpiece fused with the...

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Publicado en:Neuropharmacology
Main Authors: Tradtrantip, Lukmanee, Felix, Christian M., Spirig, Rolf, Morelli, Adriana Baz, Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322534/
https://ncbi.nlm.nih.gov/pubmed/29428821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.02.002
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