Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

High-dose i.v. Ig (IVIG) is used to treat various autoimmune and inflammatory diseases; however, the mechanism of action remains unclear. Based on the K/BxN serum transfer arthritis model in mice, IVIG suppression of inflammation has been attributed to a mechanism involving basophils and the binding...

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Detalhes bibliográficos
Main Authors: Campbell, Ian K., Miescher, Sylvia, Branch, Donald R., Mott, Patrick J., Lazarus, Alan H., Han, Dongji, Maraskovsky, Eugene, Zuercher, Adrian W., Neschadim, Anton, Leontyev, Danila, McKenzie, Brent S., Käsermann, Fabian
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025610/
https://ncbi.nlm.nih.gov/pubmed/24760152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301611
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