Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity

Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitations for patients and physicians using IVIg. These limitations have stimulated a desire to generate therapeutic alternatives that...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Washburn, Nathaniel, Schwab, Inessa, Ortiz, Daniel, Bhatnagar, Naveen, Lansing, Jonathan C., Medeiros, Amy, Tyler, Steven, Mekala, Divya, Cochran, Edward, Sarvaiya, Hetal, Garofalo, Kevin, Meccariello, Robin, Meador, James W., Rutitzky, Laura, Schultes, Birgit C., Ling, Leona, Avery, William, Nimmerjahn, Falk, Manning, Anthony M., Kaundinya, Ganesh V., Bosques, Carlos J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371931/
https://ncbi.nlm.nih.gov/pubmed/25733881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422481112
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