The RNA-binding protein Celf1 post-transcriptionally regulates p27(Kip1) and Dnase2b to control fiber cell nuclear degradation in lens development

Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, presenting a fundamental question: does signaling/transcription sufficiently explain differentiation of cells pr...

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Udgivet i:PLoS Genet
Main Authors: Siddam, Archana D., Gautier-Courteille, Carole, Perez-Campos, Linette, Anand, Deepti, Kakrana, Atul, Dang, Christine A., Legagneux, Vincent, Méreau, Agnès, Viet, Justine, Gross, Jeffrey M., Paillard, Luc, Lachke, Salil A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889275/
https://ncbi.nlm.nih.gov/pubmed/29565969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007278
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