The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development

The homeodomain transcription factors (TFs) Pax6 (OMIM: 607108) and Prox1 (OMIM: 601546) critically regulate gene expression in lens development. While PAX6 mutations in humans can cause cataract, aniridia, microphthalmia and anophthalmia, among other defects, Prox1 deletion in mice causes severe le...

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Publicado no:Hum Genet
Main Authors: Aryal, Sandeep, Viet, Justine, Weatherbee, Bailey A. T., Siddam, Archana D., Hernandez, Francisco G., Gautier-Courteille, Carole, Paillard, Luc, Lachke, Salil A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572558/
https://ncbi.nlm.nih.gov/pubmed/32594240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-020-02195-7
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