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The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development
The homeodomain transcription factors (TFs) Pax6 (OMIM: 607108) and Prox1 (OMIM: 601546) critically regulate gene expression in lens development. While PAX6 mutations in humans can cause cataract, aniridia, microphthalmia and anophthalmia, among other defects, Prox1 deletion in mice causes severe le...
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| Publicat a: | Hum Genet |
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| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7572558/ https://ncbi.nlm.nih.gov/pubmed/32594240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-020-02195-7 |
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