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Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen
The specificity of tyrosine kinases is attributed predominantly to localization effects dictated by non-catalytic domains. We developed a method to profile the specificities of tyrosine kinases by combining bacterial surface-display of peptide libraries with next-generation sequencing. Using this, w...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5889215/ https://ncbi.nlm.nih.gov/pubmed/29547119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35190 |
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