A novel MDSC-induced PD-1(−)PD-L1(+) B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that suppress T-cell activity in a tumor microenvironment. However, the suppressive function of MDSCs on B cells and its underlying mechanism remain unclear. Here, we show that in 4T1 breast cancer mice, a significan...

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Udgivet i:Oncoimmunology
Main Authors: Shen, Meng, Wang, Jian, Yu, Wenwen, Zhang, Chen, Liu, Min, Wang, Kaiyuan, Yang, Lili, Wei, Feng, Wang, Shizhen Emily, Sun, Qian, Ren, Xiubao
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889195/
https://ncbi.nlm.nih.gov/pubmed/29632731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1413520
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