Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer

OBJECTIVE: Patients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand and patient outcomes. The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide (M3G) levels. Hence, the effects o...

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Udgivet i:Cancer Biol Med
Main Authors: Wang, Kaiyuan, Wang, Jian, Liu, Ting, Yu, Wenwen, Dong, Nan, Zhang, Chen, Xia, Wenbin, Wei, Feng, Yang, Lili, Ren, Xiubao
Format: Artigo
Sprog:Inglês
Udgivet: Compuscript 2021
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7877184/
https://ncbi.nlm.nih.gov/pubmed/33628591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20892/j.issn.2095-3941.2020.0442
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