Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been clearly established. Here we found that rTg4510 mice, which overexpress human mutant tau in the forebrain, develop progressive age-dependent...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Wang, Xiaohai, Smith, Karen, Pearson, Michelle, Hughes, Anna, Cosden, Mali L., Marcus, Jacob, Hess, J. Fred, Savage, Mary J., Rosahl, Thomas, Smith, Sean M., Schachter, Joel B., Uslaner, Jason M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889169/
https://ncbi.nlm.nih.gov/pubmed/29624602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195486
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