Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

Although tau pathology, behavioral deficits, and neuronal loss are observed in patients with tauopathies, the relationship between these endpoints has not been clearly established. Here we found that rTg4510 mice, which overexpress human mutant tau in the forebrain, develop progressive age-dependent...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wang, Xiaohai, Smith, Karen, Pearson, Michelle, Hughes, Anna, Cosden, Mali L., Marcus, Jacob, Hess, J. Fred, Savage, Mary J., Rosahl, Thomas, Smith, Sean M., Schachter, Joel B., Uslaner, Jason M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889169/
https://ncbi.nlm.nih.gov/pubmed/29624602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195486
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