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Tyrosines-740/751 of PDGFRβ contribute to the activation of Akt/Hif1α/TGFβ nexus to drive high glucose-induced glomerular mesangial cell hypertrophy

Glomerular mesangial cell hypertrophy contributes to the complications of diabetic nephropathy. The mechanism by which high glucose induces mesangial cell hypertrophy is poorly understood. Here we explored the role of the platelet-derived growth factor receptor-β (PDGFRβ) tyrosine kinase in driving...

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Dettagli Bibliografici
Pubblicato in:Cell Signal
Autori principali: Das, Falguni, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889140/
https://ncbi.nlm.nih.gov/pubmed/28951244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2017.09.017
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