Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

Tissue factor (TF) is the primary activator of the blood coagulation cascade. Liver parenchymal cells (ie, hepatocytes) express TF in a molecular state that lacks procoagulant activity. Hepatocyte apoptosis is an important feature of acute and chronic liver diseases, and Fas-induced apoptosis increa...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Kopec, Anna K, Spada, Alfred P, Contreras, Patricia C, Mackman, Nigel, Luyendyk, James P
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Caspase Inhibition and Hepatic Tissue Factor-Mediated Coagulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888917/
https://ncbi.nlm.nih.gov/pubmed/29228388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx268
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