Replication stress induces accumulation of FANCD2 at central region of large fragile genes

During mild replication stress provoked by low dose aphidicolin (APH) treatment, the key Fanconi anemia protein FANCD2 accumulates on common fragile sites, observed as sister foci, and protects genome stability. To gain further insights into FANCD2 function and its regulatory mechanisms, we examined...

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Τόπος έκδοσης:Nucleic Acids Res
Κύριοι συγγραφείς: Okamoto, Yusuke, Iwasaki, Watal M, Kugou, Kazuto, Takahashi, Kazuki K, Oda, Arisa, Sato, Koichi, Kobayashi, Wataru, Kawai, Hidehiko, Sakasai, Ryo, Takaori-Kondo, Akifumi, Yamamoto, Takashi, Kanemaki, Masato T, Taoka, Masato, Isobe, Toshiaki, Kurumizaka, Hitoshi, Innan, Hideki, Ohta, Kunihiro, Ishiai, Masamichi, Takata, Minoru
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2018
Θέματα:
Genome Integrity, Repair and Replication
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5888676/
https://ncbi.nlm.nih.gov/pubmed/29394375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky058
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