An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers

FGFR3 alterations (mutations or translocation) are among the most frequent genetic events in bladder carcinoma. They lead to an aberrant activation of FGFR3 signaling, conferring an oncogenic dependence, which we studied here. We discovered a positive feedback loop, in which the activation of p38 an...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Mahe, Mélanie, Dufour, Florent, Neyret‐Kahn, Hélène, Moreno‐Vega, Aura, Beraud, Claire, Shi, Mingjun, Hamaidi, Imene, Sanchez‐Quiles, Virginia, Krucker, Clementine, Dorland‐Galliot, Marion, Chapeaublanc, Elodie, Nicolle, Remy, Lang, Hervé, Pouponnot, Celio, Massfelder, Thierry, Radvanyi, François, Bernard‐Pierrot, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887543/
https://ncbi.nlm.nih.gov/pubmed/29463565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708163
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