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Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
RIG-I (retinoic acid inducible gene-I) is a cytosolic innate immune protein that senses viral dsRNA with a 5′-triphosphate overhang. Upon interaction with dsRNA a de-repression of the RIG-I CARD domains takes place that ultimately leads to the production of type I interferons and pro-inflammatory cy...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5887321/ https://ncbi.nlm.nih.gov/pubmed/29346611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1307 |
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