Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation

Activation of the type I interferon (IFN) pathway by small interfering RNA (siRNA) is a major contributor to the off-target effects of RNA interference in mammalian cells. While IFN induction complicates gene function studies, immunostimulation by siRNAs may be beneficial in certain therapeutic sett...

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Detalhes bibliográficos
Main Authors: Kenworthy, Rachael, Lambert, Diana, Yang, Feng, Wang, Nan, Chen, Zihong, Zhu, Haizhen, Zhu, Fanxiu, Liu, Chen, Li, Kui, Tang, Hengli
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770676/
https://ncbi.nlm.nih.gov/pubmed/19729514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp714
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