SHP2 regulates skeletal cell fate by modifying SOX9 expression and transcriptional activity

Chondrocytes and osteoblasts differentiate from a common mesenchymal precursor, the osteochondroprogenitor (OCP), and help build the vertebrate skeleton. The signaling pathways that control lineage commitment for OCPs are incompletely understood. We asked whether the ubiquitously expressed protein-t...

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Pubblicato in:Bone Res
Autori principali: Zuo, Chunlin, Wang, Lijun, Kamalesh, Raghavendra M., Bowen, Margot E., Moore, Douglas C., Dooner, Mark S., Reginato, Anthony M., Wu, Qian, Schorl, Christoph, Song, Yueming, Warman, Matthew L., Neel, Benjamin G., Ehrlich, Michael G., Yang, Wentian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886981/
https://ncbi.nlm.nih.gov/pubmed/29644115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-018-0013-z
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