SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes

Transdifferentiation of hypertrophic chondrocytes into bone-forming osteoblasts has been reported, yet the underlying molecular mechanism remains incompletely understood. SHP2 is an ubiquitously expressed cytoplasmic protein tyrosine phosphatase. SHP2 loss-of-function mutations in chondroid cells ar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Lijun, Huang, Jiahui, Moore, Douglas C., Zuo, Chunlin, Wu, Qian, Xie, Liqin, von der Mark, Klaus, Yuan, Xin, Chen, Di, Warman, Matthew L., Ehrlich, Michael G., Yang, Wentian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629218/
https://ncbi.nlm.nih.gov/pubmed/28983104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12767-9
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