SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.

Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC) patients causes benign cartilage tumors on the bone surface (exostoses) and within bones (enchondromas). To elucidate the mechanisms underlying cartilage tumor formation, we investigated the role of SHP2 in the specification, maturation...

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Hlavní autoři: Margot E Bowen, Ugur M Ayturk, Kyle C Kurek, Wentian Yang, Matthew L Warman
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS Genetics
On-line přístup:http://europepmc.org/articles/PMC4038465?pdf=render
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