Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

Loss of dystrophin protein due to mutations in the DMD gene causes Duchenne muscular dystrophy. Dystrophin loss also leads to the loss of the dystrophin glycoprotein complex (DGC) from the sarcolemma which contributes to the dystrophic phenotype. Tyrosine phosphorylation of dystroglycan has been ide...

Full description

Saved in:
Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Miller, Gaynor, Moore, Chris J., Terry, Rebecca, La Riviere, Tracy, Mitchell, Andrew, Piggott, Robert, Dear, T. Neil, Wells, Dominic J., Winder, Steve J.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886373/
https://ncbi.nlm.nih.gov/pubmed/22810924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds293
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items