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γ‐Secretase Dependent Nuclear Targeting of Dystroglycan

Dystroglycan is frequently lost in adenocarcinoma. α‐dystroglycan is known to become hypoglycosylated due to transcriptional silencing of LARGE, whereas β‐dystroglycan is proteolytically cleaved and degraded. The mechanism and proteases involved in the cleavage events affecting β‐dystroglycan are po...

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Bibliografiske detaljer
Udgivet i:J Cell Biochem
Main Authors: Leocadio, Daniel, Mitchell, Andrew, Winder, Steve J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982099/
https://ncbi.nlm.nih.gov/pubmed/26990187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25537
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