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γ‐Secretase Dependent Nuclear Targeting of Dystroglycan

Dystroglycan is frequently lost in adenocarcinoma. α‐dystroglycan is known to become hypoglycosylated due to transcriptional silencing of LARGE, whereas β‐dystroglycan is proteolytically cleaved and degraded. The mechanism and proteases involved in the cleavage events affecting β‐dystroglycan are po...

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Pubblicato in:J Cell Biochem
Autori principali: Leocadio, Daniel, Mitchell, Andrew, Winder, Steve J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982099/
https://ncbi.nlm.nih.gov/pubmed/26990187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25537
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