Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

Loss of dystrophin protein due to mutations in the DMD gene causes Duchenne muscular dystrophy. Dystrophin loss also leads to the loss of the dystrophin glycoprotein complex (DGC) from the sarcolemma which contributes to the dystrophic phenotype. Tyrosine phosphorylation of dystroglycan has been ide...

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Pubblicato in:Hum Mol Genet
Autori principali: Miller, Gaynor, Moore, Chris J., Terry, Rebecca, La Riviere, Tracy, Mitchell, Andrew, Piggott, Robert, Dear, T. Neil, Wells, Dominic J., Winder, Steve J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886373/
https://ncbi.nlm.nih.gov/pubmed/22810924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds293
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