Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide

Usher syndrome type 1C (USH1C/harmonin) is associated with profound retinal, auditory and vestibular dysfunction. We have previously reported on an antisense oligonucleotide (ASO-29) that dramatically improves auditory function and balance behavior in mice homozygous for the harmonin mutation Ush1c...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Hum Mol Genet
Autores principales: Vijayakumar, Sarath, Depreux, Frederic F., Jodelka, Francine M., Lentz, Jennifer J., Rigo, Frank, Jones, Timothy A., Hastings, Michelle L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886244/
https://ncbi.nlm.nih.gov/pubmed/28633508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx234
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares