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Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide
Usher syndrome type 1C (USH1C/harmonin) is associated with profound retinal, auditory and vestibular dysfunction. We have previously reported on an antisense oligonucleotide (ASO-29) that dramatically improves auditory function and balance behavior in mice homozygous for the harmonin mutation Ush1c...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886244/ https://ncbi.nlm.nih.gov/pubmed/28633508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx234 |
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