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Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules
Inherited mitochondrial optic neuropathies, such as Leber’s hereditary optic neuropathy (LHON) and Autosomal dominant optic atrophy (ADOA) are caused by mutant mitochondrial proteins that lead to defects in mitochondrial complex 1-driven ATP synthesis, and cause specific retinal ganglion cell (RGC)...
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| Publicado no: | Hum Mol Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886243/ https://ncbi.nlm.nih.gov/pubmed/29040550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx373 |
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