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Rescue of cell death and inflammation of a mouse model of complex 1-mediated vision loss by repurposed drug molecules
Inherited mitochondrial optic neuropathies, such as Leber’s hereditary optic neuropathy (LHON) and Autosomal dominant optic atrophy (ADOA) are caused by mutant mitochondrial proteins that lead to defects in mitochondrial complex 1-driven ATP synthesis, and cause specific retinal ganglion cell (RGC)...
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| Gepubliceerd in: | Hum Mol Genet |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886243/ https://ncbi.nlm.nih.gov/pubmed/29040550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx373 |
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