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Identification of small molecules that improve ATP synthesis defects conferred by Leber’s hereditary optic neuropathy mutations
Inherited mitochondrial complex I mutations cause blinding Leber's hereditary Optic Neuropathy (LHON), for which no curative therapy exists. A specific biochemical consequence of LHON mutations in the presence of trace rotenone was observed: deficient complex I-dependent ATP synthesis (CIDAS) a...
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| Publicado no: | Mitochondrion |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5039017/ https://ncbi.nlm.nih.gov/pubmed/27497748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2016.08.002 |
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