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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby prev...
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| 出版年: | Hum Mol Genet |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886221/ https://ncbi.nlm.nih.gov/pubmed/29281014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx432 |
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