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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby prev...

詳細記述

保存先:
書誌詳細
出版年:Hum Mol Genet
主要な著者: Song, Wan, Zsindely, Nóra, Faragó, Anikó, Marsh, J Lawrence, Bodai, László
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886221/
https://ncbi.nlm.nih.gov/pubmed/29281014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx432
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