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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby prev...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Song, Wan, Zsindely, Nóra, Faragó, Anikó, Marsh, J Lawrence, Bodai, László
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886221/
https://ncbi.nlm.nih.gov/pubmed/29281014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx432
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