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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby prev...
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| Published in: | Hum Mol Genet |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886221/ https://ncbi.nlm.nih.gov/pubmed/29281014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx432 |
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