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Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby prev...

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Bibliografiska uppgifter
I publikationen:Hum Mol Genet
Huvudupphovsmän: Song, Wan, Zsindely, Nóra, Faragó, Anikó, Marsh, J Lawrence, Bodai, László
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886221/
https://ncbi.nlm.nih.gov/pubmed/29281014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx432
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