PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

BACKGROUND: PD-L1 expression in tumour tissues is widely used to select patients to receive anti-PD-1/PD-L1 antibodies, but data are lacking on the correlation of plasma PD-L1 levels with the effect of treatments. METHODS: To investigate the association between PD-L1 mRNA in plasma-derived exosomes...

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Vydáno v:Br J Cancer
Hlavní autoři: Del Re, Marzia, Marconcini, Riccardo, Pasquini, Giulia, Rofi, Eleonora, Vivaldi, Caterina, Bloise, Francesco, Restante, Giuliana, Arrigoni, Elena, Caparello, Chiara, Bianco, Maria Grazia, Crucitta, Stefania, Petrini, Iacopo, Vasile, Enrico, Falcone, Alfredo, Danesi, Romano
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886129/
https://ncbi.nlm.nih.gov/pubmed/29509748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2018.9
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