Concise Review: Chronic Myeloid Leukemia: Stem Cell Niche and Response to Pharmacologic Treatment

Nowadays, more than 90% of patients affected by chronic myeloid leukemia (CML) survive with a good quality of life, thanks to the clinical efficacy of tyrosine kinase inhibitors (TKIs). Nevertheless, point mutations of the ABL1 pocket occurring during treatment may reduce binding of TKIs, being resp...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Transl Med
Autori principali: Arrigoni, Elena, Del Re, Marzia, Galimberti, Sara, Restante, Giuliana, Rofi, Eleonora, Crucitta, Stefania, Baratè, Claudia, Petrini, Mario, Danesi, Romano, Di Paolo, Antonello
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Translational Research Articles and Reviews
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5827745/
https://ncbi.nlm.nih.gov/pubmed/29418079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.17-0175
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