Genetic analysis of Wnt/PCP genes in neural tube defects

BACKGROUND: Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube closure (NTC). Knockout mice that are heterozygotes of single PCP genes likely fai...

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Bibliographic Details
Published in:BMC Med Genomics
Main Authors: Chen, Zhongzhong, Lei, Yunping, Cao, Xuanye, Zheng, Yufang, Wang, Fang, Bao, Yihua, Peng, Rui, Finnell, Richard H., Zhang, Ting, Wang, Hongyan
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885375/
https://ncbi.nlm.nih.gov/pubmed/29618362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-018-0355-9
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