MafB is a novel enhancer of oncogenic Notch signaling in T-cell acute lymphoblastic leukemia

Although activating NOTCH1 mutations in human T-cell acute lymphoblastic leukemia (T-ALL) are common, these naturally occurring Notch1 mutant alleles fail to efficiently induce leukemia in murine models. We performed a gain-of-function screen to identify gene products that enhanced signaling of leuk...

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Опубликовано в: :Sci Signal
Главные авторы: Pajcini, Kostandin V., Xu, Lanwei, Shao, Lijian, Petrovic, Jelena, Palasiewicz, Karol, Ohtani, Yumi, Bailis, Will, Lee, Curtis, Wertheim, Gerald B., Mani, Rajeswaran, Muthusamy, Natarajan, Li, Yunlei, Meijerink, Jules P.P., Blacklow, Stephen C., Faryabi, Robert B., Cherry, Sara, Pear, Warren S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885022/
https://ncbi.nlm.nih.gov/pubmed/29138297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam6846
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