IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their in vitro neutralizing activity engaging their Fab region. However, anti-HIV-1 Abs also mediate a broad array of Fc-mediated effector functions including Ab-dependent cellular cytot...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Duchemin, Maxence, Khamassi, Marwa, Xu, Lin, Tudor, Daniela, Bomsel, Morgane
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884934/
https://ncbi.nlm.nih.gov/pubmed/29651286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00244
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