The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating effector functions. We here interrogate this paradigm by evaluating the unique influence of the CH1α domain on epitope specificity and functions...

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Pubblicato in:PLoS Pathog
Autori principali: Khamassi, Marwa, Xu, Lin, Rey, Julien, Duchemin, Maxence, Bouceba, Tahar, Tuffery, Pierre, Tudor, Daniela, Bomsel, Morgane
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802955/
https://ncbi.nlm.nih.gov/pubmed/33315937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009103
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