The CH1α domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals

The antibody molecule comprises a variable domain conferring antigen specificity and affinity distinct from the heavy chain constant (CH) domains dictating effector functions. We here interrogate this paradigm by evaluating the unique influence of the CH1α domain on epitope specificity and functions...

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Publicat a:PLoS Pathog
Autors principals: Khamassi, Marwa, Xu, Lin, Rey, Julien, Duchemin, Maxence, Bouceba, Tahar, Tuffery, Pierre, Tudor, Daniela, Bomsel, Morgane
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7802955/
https://ncbi.nlm.nih.gov/pubmed/33315937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009103
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