SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells

BACKGROUND: Hemorrhagic transformation is a major complication of ischemic stroke, is linked to matrix metalloproteinase-9 (MMP-9), and is exacerbated by tissue plasminogen activator (tPA). Cerebral ischemia/reperfusion is characterized by SUR1-TRPM4 (sulfonylurea receptor 1—transient receptor poten...

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Udgivet i:PLoS One
Main Authors: Gerzanich, Volodymyr, Kwon, Min Seong, Woo, Seung Kyoon, Ivanov, Alexander, Simard, J. Marc
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884564/
https://ncbi.nlm.nih.gov/pubmed/29617457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195526
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