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SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells
BACKGROUND: Hemorrhagic transformation is a major complication of ischemic stroke, is linked to matrix metalloproteinase-9 (MMP-9), and is exacerbated by tissue plasminogen activator (tPA). Cerebral ischemia/reperfusion is characterized by SUR1-TRPM4 (sulfonylurea receptor 1—transient receptor poten...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884564/ https://ncbi.nlm.nih.gov/pubmed/29617457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195526 |
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