The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

BACKGROUND: Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca(2+)-sensitive calcineurin (CN) dephosphorylating nucl...

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Pubblicato in:J Neuroinflammation
Autori principali: Kurland, David B., Gerzanich, Volodymyr, Karimy, Jason K., Woo, Seung Kyoon, Vennekens, Rudi, Freichel, Marc, Nilius, Bernd, Bryan, Joseph, Simard, J. Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888589/
https://ncbi.nlm.nih.gov/pubmed/27246103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0599-2
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