The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

BACKGROUND: Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca(2+)-sensitive calcineurin (CN) dephosphorylating nucl...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Kurland, David B., Gerzanich, Volodymyr, Karimy, Jason K., Woo, Seung Kyoon, Vennekens, Rudi, Freichel, Marc, Nilius, Bernd, Bryan, Joseph, Simard, J. Marc
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888589/
https://ncbi.nlm.nih.gov/pubmed/27246103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0599-2
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