The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

BACKGROUND: Harmful effects of activated microglia are due, in part, to the formation of peroxynitrite radicals, which is attributable to the upregulation of inducible nitric oxide (NO) synthase (NOS2). Because NOS2 expression is determined by Ca(2+)-sensitive calcineurin (CN) dephosphorylating nucl...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Neuroinflammation
Auteurs principaux: Kurland, David B., Gerzanich, Volodymyr, Karimy, Jason K., Woo, Seung Kyoon, Vennekens, Rudi, Freichel, Marc, Nilius, Bernd, Bryan, Joseph, Simard, J. Marc
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4888589/
https://ncbi.nlm.nih.gov/pubmed/27246103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0599-2
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires