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Targeting renal glucose reabsorption to treat hyperglycaemia: the pleiotropic effects of SGLT2 inhibition

Healthy kidneys filter ~160 g/day of glucose (~30% of daily energy intake) under euglycaemic conditions. To prevent valuable energy from being lost in the urine, the proximal tubule avidly reabsorbs filtered glucose up to a limit of ~450 g/day. When blood glucose levels increase to the point that th...

詳細記述

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書誌詳細
出版年:Diabetologia
主要な著者: Vallon, Volker, Thomson, Scott C.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884445/
https://ncbi.nlm.nih.gov/pubmed/27878313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-4157-3
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