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Why Do SGLT2 Inhibitors Inhibit Only 30–50% of Renal Glucose Reabsorption in Humans?

Sodium glucose cotransporter 2 (SGLT2) inhibition is a novel and promising treatment for diabetes under late-stage clinical development. It generally is accepted that SGLT2 mediates 90% of renal glucose reabsorption. However, SGLT2 inhibitors in clinical development inhibit only 30–50% of the filter...

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Detalhes bibliográficos
Main Authors: Liu, Jiwen (Jim), Lee, TaeWeon, DeFronzo, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425428/
https://ncbi.nlm.nih.gov/pubmed/22923645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0052
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