Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice

Ko143 is a reference inhibitor of the adenosine triphosphate-binding cassette (ABC) transporter breast cancer resistance protein (humans: ABCG2, rodents: Abcg2) for in vitro and in vivo use. Previous in vitro data indicate that Ko143 binds specifically to ABCG2/Abcg2, suggesting a potential utility...

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Udgivet i:Eur J Pharm Sci
Main Authors: Mairinger, Severin, Zoufal, Viktoria, Wanek, Thomas, Traxl, Alexander, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Kuntner, Claudia, Pahnke, Jens, Müller, Markus, Langer, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884419/
https://ncbi.nlm.nih.gov/pubmed/29360507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2018.01.034
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