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Engineering metabolic pathways in Amycolatopsis japonicum for the optimization of the precursor supply for heterologous brasilicardin congeners production
The isoprenoid brasilicardin A is a promising immunosuppressant compound with a unique mode of action, high potency and reduced toxicity compared to today's standard drugs. However, production of brasilicardin has been hampered since the producer strain Nocardia terpenica IFM0406 synthesizes br...
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| Pubblicato in: | Synth Syst Biotechnol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
KeAi Publishing
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884276/ https://ncbi.nlm.nih.gov/pubmed/29911199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2017.12.005 |
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