Genetic Engineering in Combination with Semi‐Synthesis Leads to a New Route for Gram‐Scale Production of the Immunosuppressive Natural Product Brasilicardin A

Brasilicardin A (1) consists of an unusual anti/syn/anti‐perhydrophenanthrene skeleton with a carbohydrate side chain and an amino acid moiety. It exhibits potent immunosuppressive activity, yet its mode of action differs from standard drugs that are currently in use. Further pre‐clinical evaluation...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Botas, Alma, Eitel, Michael, Schwarz, Paul N., Buchmann, Anina, Costales, Paula, Núñez, Luz Elena, Cortés, Jesús, Morís, Francisco, Krawiec, Michał, Wolański, Marcin, Gust, Bertolt, Rodriguez, Mirna, Fischer, Wolf‐Nicolas, Jandeleit, Bernd, Zakrzewska‐Czerwińska, Jolanta, Wohlleben, Wolfgang, Stegmann, Evi, Koch, Pierre, Méndez, Carmen, Gross, Harald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2021
Konular:
Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251711/
https://ncbi.nlm.nih.gov/pubmed/33768597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015852
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